Secondary chromosomal abnormalities in acute lymphoblastic leukemia
نویسندگان
چکیده
منابع مشابه
Chromosomal abnormalities in Pakistani children with acute lymphoblastic leukemia.
BACKGROUND Cytogenetic abnormalities have important implications in diagnosis and prognosis of acute leukemia and are now considered an important part of the diagnostic workup at presentation. Karyotype, if known at the time of diagnosis, guides physicians to plan appropriate management strategies for their patients. AIM AND OBJECTIVES To determine the cytogenetic profile of acute lymphoblast...
متن کاملChromosomal Abnormalities in Acute Lymphoblastic Leukemia1
Chromosome abnormalities in acute lymphoblastic leukemia (ALL) and their possible clinical significance are briefly re viewed based upon the literature and 60 cases studied at the University of Minnesota. Almost all cases of ALL appear to demonstrate clonal abnormalities; the major abnormal clone is usually hyperdiploid or pseudodiploid. Among cases of non-T, non-B ALL, at least four translocat...
متن کاملChildhood acute lymphoblastic leukemia with chromosomal breakpoints
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متن کاملGenetic abnormalities associated with acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) occurs with high frequency in childhood and is associated with high mortality in adults. Recent technical advances in next-generation sequencing have shed light on genetic abnormalities in hematopoietic stem/progenitor cells as the precursor to ALL pathogenesis. Based on these genetic abnormalities, ALL is now being reclassified into newly identified subtypes....
متن کاملFrequency of chromosomal abnormalities in Pakistani adults with acute lymphoblastic leukemia.
BACKGROUND The difference in prognosis of adult and childhood acute lymphoblastic leukemia (ALL) can be attributed largely to variation in cytogenetic abnormalities with age groups. Cytogenetic analysis in acute leukemia is now routinely used to assist patient management, particularly in terms of diagnosis, disease monitoring, prognosis and risk stratification. Knowing about cytogenetic profile...
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ژورنال
عنوان ژورنال: Caryologia
سال: 2002
ISSN: 0008-7114,2165-5391
DOI: 10.1080/00087114.2002.10797886